The four-day event focused on technology and business starts Sunday and runs through Wednesday.
It includes panel discussions, competitions for startup companies, networking opportunities for investors and entrepreneurs, as well as musical performances and other celebrity-driven events.
The events are being staged at prominent locations across the Boston-area, including City Hall Plaza, historic Faneuil Hall, the John F. Kennedy Presidential Library, the Massachusetts Institute of Technology and the Fenway Park area.
More than 7,000 people are expected to attend.
Actor Ashton Kutcher, actress Evan Rachel Wood, skier Lindsey Vonn, model Karlie Kloss and television chef Ayesha Curry are among the other notable summit speakers.