LOL! CHELSEA HANDLER IS A WILD ONE! SH!TS ON ANGELINA JOLIE!

Apparently even mothers of six aren't exempt from Chelsea Handler's bad side.

Especially if that mom happens to be Angelina Jolie.

The 35-year-old foul-mouthed comic – and close pal of Jennifer Aniston – verbally slaughtered Jolie, also 35, during a recent standup performance in New Jersey.

According to footage from the Dec. 3 show, Handler skewered Jolie's love life, friendships and even her parenting.

An expletive-laden clip posted on YouTube starts with Handler yelling at a presumably disruptive audience member, before someone makes an inaudible comment about Jolie.

"She's a homewrecker. She is," Handler replies from the stage. "And so are you. You're a homewrecker, too."

From there, the comedienne focused exclusively on Jolie, saying, "She can rescue as many babies from as many countries as she wants to [but] I don't f---ing believe you."

"She gives interviews, 'I don't have a lot of female friends.' Cause you're a f---ing c--t, that's why," Handler continued. "If you're a female and you don't have female friends, then you're a f---ing bitch."

The late-night host even brought Jolie's kids into it – a usually taboo subject for comics.

Of Maddox, Jolie's 9-year-old adopted son with partner Brad Pitt, Handler guessed, "He's probably so pissed off. He probably thought he hit the jackpot [after being] rescued [by] some A-list actress who's going to take him from third-world Cambodia, only to find out she's going to take him to every other f---ing third-world country in the universe."

"He's probably like, 'B---h, when are we going to get to Malibu?'" Handler said in the clip.

The sometimes-controversial E! talk show host defended herself on Twitter Sunday by simply noting, "I have been making fun of angelina jolie for years. Period."

Handler happened to be with Aniston, Pitt's ex-wife, just days before the Jersey show. The friends took a Thanksgiving vacation to Cabo San Lucas.

Jolie's invitation probably got lost in the mail.

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