50 Cent Responds To The Cookie Lyon Diss On Empire

Taraji P. Henson and the "Empire" writers should know ... 50 Cent doesn't sweat people taking shots at him -- been there, done that -- so, he's firing right back with a direct shot at Cookie's ... cookie.

During the "Empire" premiere ... Taraji's character made a crack about Fif being "thirsty," and it didn't take long for him to respond.

Check out the video -- 50 wants everyone to know he's got a sexual past with Cookie.

So, is it just faux TV beef, or is Fiddy really talking about Taraji? We're guessing it's door #1.

50 ate the cookie ……

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