Henson, who stars in the hit show "Empire," will portray a female sports agent trying to compete in a male-dominated world in the film titled "What Men What."
The Paramount Pictures-backed movie is slated to hit theaters in Jan. 2019.
Nancy Meyers directed the popular 2000 romantic-comedy with Mel Gibson as Nick Marshall, a New York City executive, who is given the ability to read women's minds due to a freak accident.
Helen Hunt starred in the flick as Gibson's love interest.
In the remake, Henson, 47, gains the ability to read men's minds and it gives her a leg up in the business — helping her in the race to sign the next NBA superstar, according to Deadline.